Prince Henry’s Institute

 

Peter Stanton

 

Appointments

• Honorary Senior Lecturer, Department of Biochemistry and Molecular Biology, Monash University

Research Interests

Dr Stanton's research interests lie in the hormonal regulation of cell junctions in the testis, as part of the search for testicular targets of male hormonal contraception. His work has focussed on cell junctions between Sertoli and germ cells, and more recently between Sertoli cells, with particular reference to their regulation by gonadotrophins.

He has specific skills in biomolecular separation and characterisation and has applied these skills to the assessment of serum and testicular steroids and hormones in rats, primates and men during male hormonal contraception.

More recently Dr Stanton has, with other colleagues, overseen the establishment of  a new core facility proteomics lab at PHI. Dr Stanton is now involved in various proteomic studies aimed at identifying new contraceptive targets and diagnostic markers of various conditions including male and female infertility. He is also involved with PHI colleagues in inhibin research .

 

Expertise

Molecular and proteomic assessments of reproductive tissues, biomolecular separation, in vivo and vitro models of spermatogenesis

 

Recent Achievements

• Appointed to the editorial board of the Journal of Endocrinology

• Major role in establishing a new proteomics core facility at PHI

 

Current Research

• Proteomic discovery programme in male reproduction

• Regulation of Sertoli cell junctions

• Regulation of sperm release

   

 

Selected Publications

Chen J I-C , Hannan NJ, Mak Y, Nicholls PK, Zhang J, Stanton PG, Robertson DM, Salamonsen LA and Stephens AN (2009). Proteomic characterization of mid-proliferative and mid-secretory human endometrium.  (J Prot Res, in press)

Nicholls PK, Harrison CA, Gilchrist RB, Farnworth PG & Stanton PG (2009). Growth differentiation factor 9 (GDF9) is a germ-cell regulator of Sertoli cell function. Endocrinology 150:2481-2490

Tarulli GA, Meachem SJ, Schlatt S & Stanton PG (2008)  Regulation of testicular tight junctions by gonadotrophins in the adult Djungarian hamster in vivo.  Reproduction 135: 867-877

Sluka P, O'Donnell L, McLachlan RI & Stanton PG (2008) Application of laser-capture microdissection to the analysis of gene expression in the testis. Progress In Histochemistry and Cytochemistry 42:173-201

Kaitu'u-Lino TJ, Sluka P, Foo CFH & Stanton PG (2007) Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro. Reproduction 133:1169-1179

Meachem SJ, Schlatt S, Ruwanpura SM & Stanton PG (2007) The effect of testosterone, dihydrotestosterone and estradiol on the re-initiation of spermatogenesis in the adult photoinhibited Djungarian hamster. J Endocrinol 192:553-561

Matthiesson KL, McLachlan RI, O'Donnell L, Frydenburg M, Robertson DM, Stanton PG & Meachem SJ (2006) The relative roles of FSH and LH in maintaining spermatogonial maturation and spermiation in normal men. J Clin Endocrinol Metab 91: 3962-3969

Tarulli GA, Stanton PG, Lerchl A & Meachem SJ (2006). Adult Sertoli cells are not terminally differentiated in the Djungarian hamster: Effect of FSH on proliferation and junction protein organization. Biol Reprod 74:798-806.

Sluka P, O'Donnell L, Bartles JR & Stanton PG (2006). FSH regulates the formation of adherens junctions and ectoplasmic specializations between rat Sertoli cells in vitro and in vivo. J Endocrinol 189:381-395

O'Donnell L, Meachem SJ, Stanton PG and McLachlan RI (2006). The endocrine regulation of spermatogenesis. In: Neill JD (ed), Knobil and Neill's Physiology of Reproduction (3rd ed). Elsevier, San Diego CA. pp. 1017-1069

Matthiesson KL, Stanton PG, O'Donnell L, Meachem SJ, Amory JK, Berger R, Bremner WJ & McLachlan RI (2005) Effects of testosterone and levonorgesterel combined with a 5 alpha reductase inhibitor or GnRH antagonist on spermatogenesis and intratesticular steroid levels in normal men. J Clin Endocrinol Metab 90:5647-5655.

Meachem SJ, Robertson DM, Wreford NG, McLachlan RI & Stanton PG (2005) Estrogen does not effect the restoration of spermatogonial number in the GnRH-immunised adult rat. J Endocrinol 185:529-538.

McLachlan RI, O'Donnell L, Meachem SJ, Stanton PG, de Kretser DM, Pratis K & Robertson DM (2002) Identification of specific sites of hormonal regulation in spermatogenesis in rats, monkeys and man. Recent Progress in Hormone Research 57:149-179.