Prince Henry’s Institute

 

Colin Clyne

 

Appointments

• NHMRC RD Wright Fellow

• Adjunct Lecturer, Monash University, Department of Biochemistry & Molecular Biology

 

Profile

Colin received his PhD in pharmacology from the University of Edinburgh in 1994. He trained as a postdoctoral fellow at the University of Texas Southwestern Medical Centre, Dallas between 1994 and 1998 where he developed a keen interest in gene expression and cancer. He joined PHI in 1998.

 

Current Research

• Nuclear receptor pharmacology

• Breast-specific anti-oestrogens
  

• Oestrogen regulation in breast cancer
  

• Aromatase and post-transcriptional regulation

Recent Achievements

Recipient of project grant funding from:

• NHMRC (2004, 2008)

• National Breast Cancer Foundation (2006)

• Cancer Council of Victoria (2006)

• Victorian Breast Cancer Research Consortium (2009)

• Recipient of NHMRC Career Development Fellowship (2005)

• Awarded a sabbatical travel grant from the International Union against Cancer (2007)

 

Service to Scientific Community

• Editorial Board member, Endocrinology

• Editorial Board member, Journal of Molecular Endocrinology

 

Selected Publications

Chand AL, Simpson ER, Clyne CD (2009) Aromatase expression is increased in BRCA1 mutation carriers. BMC Breast Cancer 9, 148.

Clyne CD, Chang C-Y, Safi R, Fuller PJ, McDonnell DP, Young MJ (2008) Purification and characterization of recombinant human mineralocorticoid receptor. Mol Cell Endocrinol 302:81-5.

McInnes KJ, Brown KA, Knower KC, Chand AL, Clyne CD, Simpson ER (2008). Characterisation of aromatase expression in the human adipocyte cell line SGBS. Breast Cancer Res Treat 112:429-435.

Maffei L, Rochira V, Zirilli L, Antunez P, Aranda C, Fabre B, Simone ML, Pignatti E, Simpson ER, Houssami S, Clyne CD, Carani C (2007)  A novel compound heterozygous mutation of the aromatase gene in an adult man: reinforced evidence on the relationship between congenital oestrogen deficiency, adiposity and the metabolic syndrome. Clin Endocrinol 67:218-227.

Miki Y, Clyne CD, Suzuki T, Moriya T, Nakamura Y, Ishida T, Yabuki N, Kitada K, Hayashi S-i, Sasano H (2006) Immunolocalization of liver receptor homologue-1 (LRH-1) in human breast carcinoma: possible regulator of in situ steroidogenesis.  Cancer Lett 244: 24-33.

Pathirage N, Di Nezza LA, Salamonsen LA, Jobling T, Simpson ER, Clyne CD (2006).  Expression of aromatase, estrogen receptors and their co-activators in patients with endometrial cancer.  Fertility and Sterility, 86:469-472.

Safi R, Kovacic A, Gaillard S, Murata Y, Simpson ER, McDonnell DP, Clyne CD. (2005).  Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.  Cancer Res 65:11762-70.

Zhou J, Suzuki T, Kovacic A, Saito R, Miki Y, Ishida T, Moriya T, Simpson ER, Sasano H, Clyne CD (2005) Interactions between Prostaglandin E2, Liver Receptor Homologue-1 (LRH-1) and aromatase in breast cancer. Cancer Res  65:657-63.

Watanabe M, Simpson ER, Pathirage N, Nakajin, S, Clyne CD (2004) P450 aromatase in human foetal osteoblastic cell line SV-HFO.  J.Mol.Endo 32:533-545.

Pezzi V, Sirianni R, Chimento A, Maggiolini M, Bourguiba S, Delalande C, Carreau  S, Andò S, Simpson ER, Clyne CD (2004)  Differential expression of SF-1/AD4BP and LRH-1/FTF in the rat testis:  LRH-1 as a potential regulator of testicular aromatase expression. Endocrinology 145:2186-96.