Prince Henry’s Institute

 

Anne Corbould

 

Appointments

• Honorary Senior Lecturer, Department of Physiology, Monash University

• Endocrinologist, Launceston General Hospital and Monash Medical Centre

• Clinical Lecturer, School of Medicine, University of Tasmania

 

Profile

Anne Corbould is a physician/scientist: admitted FRACP (Endocrinology) 1994, awarded PhD 1999 (Flinders University of South Australia). Her post doctoral positions were with Professor Andrea Dunaif (Harvard Medical School 1999-2002) and Professor Evan Simpson (PHI 2003-2006). She combines basic research at PHI with part-time clinical endocrinology (Launceston General Hospital and Monash Medical Centre).

 

Research Interests

Dual training in clinical endocrinology and basic science has enabled Anne to take a bedside-to-bench view of a common clinical problem in women, androgen excess. In reproductive-aged women, the most frequent cause of androgen excess is polycystic ovary syndrome (PCOS).

Her recent research has shown that testosterone causes insulin resistance in the adipose cells of women: thus androgen excess may have implications for the risk of metabolic disorders in women, especially type 2 diabetes.

Her recent studies have also shown that spironolactone, a drug commonly used to treat women with androgen excess, has potentially beneficial effects on glucose metabolism and inflammation in female adipose cells.

  

Recent Achievements

• 2009-2012 - NHMRC Health Professional Training Fellowship

 

Current Research

• Regulation of adipose tissue metabolism in women

 

Selected Publications

Corbould A. Insulin resistance in skeletal muscle and adipose tissue in polycystic ovary syndrome: are the molecular mechanisms distinct from type 2 diabetes?  Panminerva Med 2008;50:279-294

Corbould A. Effects of androgens on insulin action in women: is androgen excess a component of female metabolic syndrome? Diab Met Res Rev 2008;24:520-532

Corbould A. Effects of spironolactone on glucose transport and interleukin-6 secretion in adipose cells of women.  Horm Metab Res 2007;39:915-918

Corbould A, Dunaif A. The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome.  Metabolism 2007;56:716-722.

Corbould A. Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women.  J Endocrinol 2007;192:585-594.

McInnes KJ, Corbould A, Simpson ER, Jones ME. Regulation of 5',monophosphate-activated protein kinase and lipogenesis by androgens contributes to visceral obesity in an estrogen-deficient state.  Endocrinology 2006;147:5907-5913.

Corbould A*, Zhao H*, Mirzoeva S, Aird F, Dunaif A. Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome. Diabetes 2006;55:751-759. *joint first authorship

Corbould A, Kim Y-B, Youngren J, Pender C, Kahn B, Lee A, Dunaif A. Insulin resistance in the skeletal muscle of women with polycystic ovary syndrome involves both intrinsic and acquired defects in insulin signaling.   Am J Physiol Endocrinol Metab 2005;288:1047-1054.

Corbould AM, Bawden MJ, Lavranos TC, Rodgers RJ, Judd SJ. The effect of obesity on the ratio of type 3 17ß-hydroxysteroid dehydrogenase mRNA to cytochrome P450 aromatase mRNA in subcutaneous abdominal and intra-abdominal adipose tissue of women. Int J Obes 2002;26:165-175.

Rui L, Aguirre V, Kim JK, Shulman GI, Lee A, Corbould A, Dunaif A, White MF. Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser³⁰⁷ via distinct pathways.  J Clin Invest 2001;107:181-189.

Venkatesan A, Dunaif A, Corbould A. Insulin resistance in PCOS: progress and paradoxes.  Rec Prog Horm Res 2001;56:295-308.