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Cardiovascular Endocrinology
Laboratory Head
Morag Young PhD
> Profile
About this Laboratory
One of our major research goals is to provide a better understanding of cardiac failure and hypertension by studying the function of the mineralocorticoid receptor (MR) in these disorders. We aim to determine the cell types in the heart in which the MR is critical for the development of heart failure and identify the ideal features of tissue-selective blockers of the receptor.
Related to Research Themes
Current Research
Mineralocorticoid Receptor in cardiovascular disease - This research uses transgenic models to determine the role of specific cell types in the heart that are important for the development of heart disease and hypertension. These studies will facilitate the development of tissue selective antagonists for the MR in the treatment of heart disease.
Identification of ligand-selective MR antagonists - We are working to identify differences in the activity of the MR in response to different ligands. This knowledge will form the basis for screening and the development of novel agents for the treatment of hypertension and cardiovascular disease.